André Venot
Postdoctoral Research Associate
Personal Information: I obtained my training in carbohydrate chemistry at the University of Alberta, Edmonton, Canada, under the supervision of Dr. R. Lemieux. My first professional position was with Chembiomed, an early carbohydrate-based biotechnology company. Next, I held a position with the Alberta Research Council and positions with Amgen in California and Boulder, Colorado. I joined the CCRC at UGA in 1998. At the CCRC I am responsible for Service Synthesis and the supervision of several Ph.D. students. In addition to a beautiful building, the CCRC offers a unique spectrum of expertise in NMR, Mass Spectrometry, Analytical Services and Carbohydrate Biochemistry.
Current Research: In my current position, I interact with both academic collaborators and non-academic customers. I also evaluate literature data from publications or patents with the aim of establishing a synthetic route for a specific target. I work to meet expected requirements such as deadlines, quantities to synthesized, purity and analytical. I enjoy my interactions with external collaborators and find contributing to a variety of projects to be very motivating. Examples of syntheses I have achieved are: glycosyltransferase substrates, sugar nucleotides, glycopeptide building blocks (5g - 10g), 13C, 15N and biotin- and spin-labeled carbohydrates, carbohydrate co-polymers, the development of a practical synthesis of N-glycosyl neuraminic acid, modification of original structures, aminoglycoside mimetics, phospholipids and substituted purines.
Publications
Vohra, Y., M. Vasan, A. Venot, and G.J. Boons. 2008. One-pot synthesis of ologosaccharides by combining reductive openings of benzylidene acetals and glycosylations. Org. Lett. 10(15), 3247-3250.
Rauvolfova, J., A. Venot, and G.J. Boons. 2008. Chemo-enzymatic synthesis of C-9 acetylated sialosides. Carbohydr. Res. 343 , 1605-1611.
Liu, S., A. Venot, L. Meng, F. Tian, K.W. Moremen, G.J. Boons and J.H. Prestegard. 2007. Spin labeled analogs of CMP-NeuAc as NMR probes of the a -2,6-sialyltransferase ST6Gal I. Chem. Biol. 14(4): 409-418.
Rao, Y., A. Venot, E.E. Swayze, R.H. Griffey and G.J. Boons. 2006. Trisaccharide mimetics of the aminoglycoside antibiotic neomycin. Org. Biomol. Chem. 4(7): 1328-1337.
Venot, A.P., E.E. Swayze, R.H. Griffey, and G.J. Boons. 2004. Disaccharide mimetics of the aminoglycoside antibiotic neamine. ChemBioChem. 5: 1228-1236.
Galan, M., A.P. Venot, R.S. Phillips, and G.J.Boons. 2004. The design and synthesis of a selective inhibitor for Fucosyltransferase VI. Org. Biomol. Chem. 2(9): 1376-1380.
Galan, M., C. Dodson, A.P. Venot, and G.J. Boons. 2004. Glycosyltransferase activity can be selectively modulated by chemical modificiations of acceptor substrates. Biorg. Med. Chem. Lett. 14: 2205-2208.
Prabhu, A., A.P. Venot, and G.J.Boons. 2003. A new set of orthogonal protecting groups for the modular synthesis of heparan sulfate fragments. Org. Lett. 5(26): 4975-4978.
Galan, M.C., A.P. Venot, J. Glushka, A. Imberty, and G.J. Boons. 2003. Chemo-enzymatic synthesis of conformationally constrained oligosaccharides. Org. Biomol. Chem. 1: 3891-3899.
Galan, M.C., A.P. Venot, and G.J. Boons. 2003. Glycosyltransferase activity can be modulated by small conformational changes of acceptor substrates. Biochemistry. 42(28): 8522-8529.
Galan, M.C., A.P. Venot, J. Glushka, A. Imberty, and G.J. Boons. 2002. Alpha-(2,6)-sialyltransferase catalyzed sialylations of conformationally constrained oligosaccharides. J. Am. Chem. Soc. 124(21): 5964-5973.
Kearns, D.B., A. P. Venot, P.J. Bonner, B. Stevens, G.J. Boons, and L.J. Shimkets. 2001. Identification of a developmental chemoattractant in Myxococcus xanthus through metabolic engineering. Proc. Natl. Acad. Sci. USA. 98(24): 13990-13994.
Jain, N. U., A. P.Venot, K. Umemoto and J. Prestegard. 2001. Distance Mapping of Protein-binding Sites using Spin-labeled Oligosaccharide ligands. Protein Sci. 10: 2393.
Otter, A., R. U. Lemieux , R. G. Ball , A.P. Venot, O. Hindsgaul and D.R. Bundle. 1999. Crystal State and Solution Conformation of the B Blood Group trisaccharide a-L-Fucp-(1-2)-[a-D-Galp-(1-3)]-b-D-Galp-OCH3. Eur. J. Biochem. 259: 295.
Nelson, R. M., A. P. Venot, M. P.Bevilacqua, R. J. Linhardt, and I. Stamenkovic. 1995. Carbohydrate-protein Interactions in Vascular Biology. Annu. Rev. Cell Dev. Biol. 11: 601.
Wlasichuk, K., M. A. Kashem, P. V. Nikrad, P. Bird, J. Cong, and A. P. Venot, 1993. Determination of the Specificity of Rat Liver Galb(1-4)GlcNAc a(2-6) Sialyltransferase and Galb(1-3/4)GlcNAc a(2-3) Sialyltransferase Using Synthetic Modified Acceptors. J. Biol. Chem. 268: 13971.
Patents
"Sialic Acids Glycosides, Antigens and Immunoadsorbents", Ratcliffe, R. M., Venot, A. P. and Abbas, Z. A., US Patents: 5,079,353, 1/07/92; 5,296,594, 3/22/94; 5,344,870, 9/06/94; 5,527,901, 6/18/96 and 5,620,902, 4/15/97.
"Methods for the Synthesis of Monofucosylated Oligosaccharides Terminating in di-N-Acetyllactosaminyl Structures and their Immunosuppressant Activity", Kashem, M. A., Venot, A. P. and Smith, R., US Patents: 5,374,655, 12/20/94 and 5,550,155, 8/27/96.
"Method for the Enzymatic Synthesis of Alpha-sialylated Oligosaccharides Glycosides", Venot, A. P., Unger, F., Kashem, M. A., Bird, P. and Mazid, A., US Patent 5,352,670, 10/4/94.
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